Emily Perkins, reprising her role as Brigitte, the younger Fitzgerald sister as she struggles to survive and combat the same infection that claimed her sister. Brigitte's journey takes her far from the suburbs of Bailey Downs to a drug rehabilitation clinic, run by Alice Seversen (Kidder), a street-smart former addict who believes Brigitte is another strung out teenage drug user like the ones she tries to help on a daily basis.

Assisting Alice at the clinic is the handsome but immoral orderly Tyler (Johnson), who it turns out, is much more interested in his own specific needs. Add into the mix the 14-year-old Miranda (Maslany), known to all as Ghost. Not at the clinic for drug problems, Ghost is in residence there to be with her bedridden grandmother as she recovers from horrible burns. Her fascination with Brigitte's problems has her playing a key role in the story. And let's not forget Ginger (Isabelle) – dead, but appearing before Brigitte as a counselling apparition to lend her own advice and words of wisdom. And finally, there is the beast - a fierce lycanthropic creature that is stalking Brigitte.