Spanning four decades, from the chaotic 1960s to the present, director Marco Tullio Giordana’s passionate epic "The Best of Youth" follows two Italian brothers through some of the most tumultuous events of recent history. In a final period of hopeful innocence, free-spirited Nicola (Luigi Lo Cascio) travels the world and settles for a life as a successful psychiatrist, while his tragically introverted and idealist brother Matteo (Alessio Boni) joins the Italian police with the hope of righting society’s wrongs. Their politics and personalities are inextricably intertwined as the world around them violently shifts and they are pushed together and pulled apart by the tides of history and their own divergent dreams.